Finally !! The old times of liposomal minoxidil are long gone. After one year of research Lipoxidil announces the breakthrough for nanospheric Minoxidil. The ultimate version of NanoSal 8 will be on the market shortly. Stay tuned. Pre-orders accepted.

As many of you have realized Lipoxidil has significantly cut back their product list. This has several reasons:

The FDA has recently contacted our US distributor with the advice that some products cannot be legally sold as cosmetics in the USA and would require a full NDA or FDA approval. We do not agree with this opinion but we do not have the financial means to argue with the FDA or file an NDA. So in honoring the FDA´s advice we have discontinued several products for the sale in the US. These products might be still available overseas. If you live in the USA please do not ask us to deliver from overseas. We cannot do it !

The continuing weakness of the US-$ against the Euro would have made it necessary to increase prices by 30 %. As our true liposomal high-tech products are already expensive we do not see a future market with the increased prices.

From desperate sounding emails we know that our innovative and unique products helped many many customers to maintain and improve their hair status and that these products are needed for continuing success. We sincerely apologize for the current situation and hope to work out a solution as fast as possible. Keep in mind that the new Lipoxidil MLL products are still available.

It´s here. Lipoxidil 20 S Lotion

Now available in the US for $ 49 !

We have received a lot of questions about the penetration properties of NanoSal shampoo.There is an article published by Salvona, Inc. which contains interesting facts about the abilities of NanoSal. Please read.

Our new experimental product t-Adenosine solution is available in a new version 3 with some changes:

° Minoxidil addition to use the synergistic effect of both ingredients possible on special request. t-Adenosine for women will be delivered without minoxidil.

° Rooibos hair growth stimulant added - Papain moved to a new product treating fibrosis ( available summer 2005 )

° liposomal delivery system adjusted

Our product contains no glycol as in the commercially available product. If you do not see Adenosine on that order page it is not available in your country.

As the 2004 Watanabe study shows Adenosine basically thickens vellus hair but does not change hair density.So it might be useful to combine Adenosine with hair growth promoting ingredients for a synergistic effect.

Brand new versions of Genistil-R ,Genistil-RM, Lipoxidil Plus and Lipoxidil 1.5 % are released for the US market. These versions are already a major success in Europe and Japan. Using new "sandwich-nanosome " technology we were able to reduce alcohol to less than 10 %. Most commercial products contain 40 to 60 % alcohol and PPG. There are some new studies showing concerns about alcohol as caspase-3 and apoptosis inducer being contraproductive for the use of topical hairloss products. Activation of caspase 3 is thought to be a direct cause of cell apoptosis

Experiments revealed that processing of caspase-3 is a principal event during apoptosis of hair cell types.Conclusion: alcohol simular as TGF-b induces caspase-3 which causes apoptosis of hair cells.Alcohol strongly reduces the positive effect of anti-hairloss ingredients and should be reduced to a minimum or elimitated at all.

Right now we are in the early stages of developing a new product which strongly inhibits TGF-b and caspase-3.It is a rather simple but very promising nanosome combination of topical Finasteride with a second well known botanical ingredient.

All Lipoxidil products are now enhanced with L-Arginine and Biotin.Our own studies have shown that both ingredients are ideal supplements to minoxidil.More about the products here.

Very interesting new study about the soy isoflavones and phytoestrogens Genistein,Daidzein and Equol. The most interesting parts are between the lines." Down-regulation of androgen-receptor protein was found to occur immediately following neonatal exposure to estradiol benzoate and then persist through adulthood indicating a permanent imprint on the ability of the prostate to express normal AR levels " Maybe in the future genetic predisposed males babies can be "vaccinated" with estradiol benzoate to prevent hairloss ? And it seems to be that phytoestrogens are more and more the key to fight hairloss in a natural way. Remarkable - the phytoestrogens were fed to the animals as part of a regular diet and nevertheless showed results. " .. it is possible that the reduction in AR expression seen in the present study are a result of high circulating phytoestrogens from diet and subsequently high steady state levels of phytoestrogens.." Of course this is a prostate study but circulating phytoestrogens will influence AR expression throughout the body. What are phytoestrogens ? Read here. For experimental purposes we have developed a pharmaceutical liposomal Genistein /  Daidzein solution ( available in Europe only ) as an additional topical treatment to suppress the androgen receptor formation especially in the scalp. AR suppression is much more effective than blocking the already existing AR.

At the side it is interesting that Genistein has also properties to reduce UVB induced damage  in human skin by inhibiting apoptosis.

Apoptosis is also involved in AGA.