Lipoxidil - The New Generation Of Hairloss Treatment

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	This brand-new invention from Europe will solve the main problem of all topical anti-hairloss products - skin penetration. Until today they were only two possibilities to infiltrate an active substance direct and free of side effects to the cells of the deeper skin layers. Either by the systemic application of drugs in form of pills or injection or by means of topical applied chemicals (mainly acids). The disadvantage of both methods is that only a few percent ( f.e. less than 3 % of Minoxidil penetrates the skin !) of the substance reaches the lower skin layers. The discovery of liposomes improved the skin penetration of a number of substances significantly but the use of the Dermaroller will improve this even further. The Dermaroller is a cylinder-shaped instrument studded with tiny, almost invisible 192 micro-spikes. They are so short (0,13 mm) and so slim (0,08 mm) that they just set an invisible micro-perforation in the uppermost skin layer (stratum corneum). This perforation will be closed again within 1 hour. Through these infiltration channels the active substance is delivered directly to the dermis. This dynamic infiltration technique has unquestionable advantages. It is efficient and free of pain. The Dermaroller is a byproduct of cosmetic research and clinically tested for the use with liposomal products but can be used with a variety of anti-hairloss products - even homemade preparations. The liposomes can penetrate the scale-like layers of the stratum corneum with some percent. From this depot they slowly seep through the epidermis towards the lower dermis. The dermaroller micro-spikes set fine infiltration channels through which the liposomes reach the dermis directly. In comparison to a usual topical preparation an improvement of skin penetration by the factor of 40 is achieved. The infiltration channels are closed again within minutes. With the help of the most advanced technology, the so-called confocal laser scanning photography, science managed to get a deeper insight into the skin. In order to make such photos a lipophilic fluorescent probe was incorporated in liposomes and applied on the skin. Three hours later the penetration of the liposomes through the stratum corneum were pictured under the scanner-microscope. conventional (f.e. regular Minoxidil ) liposomal product ( f.e. Lipoxidil ) liposomal + Dermaroller Here the written results:

	Three hours after the application and treatment with the Dermaroller C-8 a total of 28.5 % of the applied substance ( Retin-A ) was found in the stratum corneum. In the control group only 13.7 %. That means penetration into the stratum corneum has improved about 105 %. Only 3.3 % penetrated into the lower skin layers and 0.5% were found in the receptor compartment. This confirms that the Dermaroller C-8 delivers to the stratum corneum without loosing too much substance to the lower skin layers and without the risk of systemic side effects The development of the Dermaroller took almost three years. Although we were convinced that this simple instrument would exactly do what we expected right from the beginning we requested science to prove our thesis on neutral ground. The first study ( German language only ) for the efficiency for the infiltration of active substances with a new device, the Dermaroller, was carried out in spring 2001 by the Institute for Pharmaceutical Technology and Biopharmacy under the supervision of Prof. Fahr from the University of Marburg / Germany. The second study from July 2001 ( in English ) demonstrated very impressively the penetration of liposomes with the method of confocal laser scanning microscopy. How to use the Dermaroller ? The Dermaroller can and should be used with every application of an anti-hairloss product. The use is absolutely pain-free and the invisible micro perforation of the skin disappears in less than 60 minutes. The topical product has to be applied first (!!). Then use the Dermaroller with light to medium pressure. Very important - roll 2-3 times over the same spot but only in one direction. If you roll back and forth you will tangle your existing hair in the roller. Always roll away from the hair root. Use your hands to keep existing hair out of your way as good as possible. For the first days this will be an unusual and strange procedure but after a week you will be used to it ! Guaranteed! Each Dermaroller is handmade in Europe. BTW - the Dermaroller can be used for all kinds of cosmetic products ( f.e. anti-wrinkle cream ) also. If you have more questions about the Dermaroller click here for our FAQ page..