Recent studies have shown that soy-derived phytoestrogens - especially Genistein - are able to down-regulate androgen receptor (AR) expression in the prostate by about 40 % without having an effect of circulating testosterone or estrogen levels.The exact mechanism of the AR inhibiting effect of Genistein or its metabolites is still unknown. Possible tyrosine kinase inhibition or binding to the estrogen receptor are also discussed as suppression of angiogenesis.It is concluded that some phytoestrogens act as estrogen mimics and protect men from benign prostatic hyperplasia and prostate cancer .

Dihydrotestosterone (DHT) exerts its function by activation of the androgen receptor, which is a member of the family of nuclear receptors. Upon binding to androgen, the androgen receptor (AR) can translocate into the nucleus and bind to androgen response element(s) to modulate its target genes.

Therapy of prostate cancer or androgenetic alopecia is currently based on blockade of androgen receptor function by androgen depletion,by antagonists (antiandrogens) or by inhibiting 5-AR. Obviously it would be much more effective to locally reduce the AR expression than to block existing AR. The strongest easily available topical AR blocker is Spironolactone - unfortunately spiro would have to be applied each 3-4 hours due to its short half-life term. Liposomal spiro with it´s depot mechanism can improve the effects of spiro.

Now there are three newly discovered AR inhibitors - Genistein ,Quercitin and Vitamin E alpha-tocopheryl succinate.

We have encapsulated Genistein and Vitamin E succinate in nanosome liposomes for topical use.Our Genistein is 97 % pure,imported directly from China and approved for medical use.We do not use OTC Genistein capsules with low amounts of genistein and lots of fillers and starch for our topical product but we highly recommend to use Genistein caps.( at least 20 mg a day ) in addition. Genistein has the tendency to accumulate in the body which supports the topical effect of Genistil.

Next ingredient is a brand new hair growth stimulant called Rooibos. Rooibos is derived from the redbush plant - a hardy shrub indigenous to the North Western Cape of South Africa.Clinically Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems.The main ingredients of Rooibos are:

• Phenolic carboxylic acids : 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid,
4-hydroxy-3-methoxybenzoic acid, 4-hydroxy-3,5-dimethoxybenzoic acid, 4-
coumaric acid, caffeic acid, ferulic acid
• Tannins : approx. 3%; (+) – catechin, procyanidin B-3, bis-fisetinidol-catechin
• Flavone glycosides : orientin, iso-orientin, vitexin, iso-vitexin (antioxidant properties)
• Dihydrochalcone glycosides : aspalathin* nothofagin (strong antioxidants)
• Flavones, Flavonols & C-O Glycosides : luteolin, luteolin-7-0-glucoside, quercetin,
isoquercetin & rutin
• Flavonone glycosides : dihydro-orientin, dihydro-iso-orientin
• Alpha hydroxy acids : phenylpyruvic acid glucoside
• Minerals : iron, potassium, calcium, copper, zinc, manganese, sodium
• Miscellaneous : Vitamin C, pinitol (non-phenolic)

Rooibos has very potent anti-inflammatory and antioxidant properties.Quercetin is the major in vitro active component of rooibos.

Studies were initiated by Cosmetochem International Ltd. at an independent laboratory
(Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss.

A 90 day trial was conducted comparing a hair lotion containing 10% Rooibos with a placebo lotion. 5 ml of the alcoholic solutions were applied daily. MPE Rooibos is a concentrated extract of Rooibos produced by a novel dual phase extraction process which ensures the production of an extract with the widest spectrum of plant
actives i.e. polar, semi-polar and non-polar.
The efficacy of the products was evaluated using a videotrichogramme, which determines:
• hair density ( total number of hairs)
• number and proportion of telogen hairs (hairs where growth has ceased)
• number and proportion of anagen hairs (hairs which are still growing)
• hair growth speed of anagen hairs
After 90 days results showed :
• Hair growth speed
-a significant increase of the hair growth speed in the lotion containing
MPE Rooibos compared with the placebo
-an increase in the hair growth speed was observed with 89% of the
volunteers
• Product efficacy – results from a subjective evaluation questionnaire by
the volunteers showed:
67% rated hair loss as zero or low
78% saw an improvement (low to medium)
45% saw low to medium re-growth of hair

63% of volunteers found a positive effect on the fragrance and
smoothness of hair
67% liked the general aspect of their hair
• No undesirable reactions (irritation or allergy) were recorded
Conclusion : These results show that most of the volunteers had a remarkable
improvement in both the increase of the speed of hair growth, the decrease in
hair loss and an overall improvement in hair condition.

Third ingredient of Genistil-R is a relatively unknown plant extract called Sophora Flavescens.A recent study shows that Sophora flavescens has outstanding hair growth promoting and type II 5alpha-reductase activity inhibiting effects.It is suggested

that the effects of Sophora flavescens extract on hair growth may be mediated through the regulation of growth factors in dermal papilla cells.

New ingredient: Rosemary extract with potent anti-inflammatory properties

Genistil-R combines the AR inhibiting effect of Genistein and Vitamin E succinate with the hair growth promoting and anti-inflammatory properties of Rooibos ,Sophora Flavescens and Rosemary extract. It is available as a liposomal preparation in a 50 ml bottle and intended for daily use. Genistil-R has a milky color and light herbal smell.It leaves no residue. Our trial customers over the last 8 weeks have reported improvement of their hair structure within 3-5 days.As in the French study an extreme increase in hair growth speed was observed.Genistil-R works excellent in preventing hairloss and improving thinning areas. We recommend a 1-2 week treatment period with InFlamil before or together with Genistil-R.